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INSTITUTE FOR IMMUNOLOGY FACULTY
| Michael Demetriou, M.D. |
| Fields of Study: |
| The molecular biology and glycobiology of T cell dysfunction in organ specific autoimmunity. |
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| Research Interests: |
| Dr. Demetriou's laboratory focuses on the molecular biology and glycobiology of T cell function in relation to autoimmune diseases. His lab has recently identified beta1,6 N-acetylglucosaminyltransferase V (Mgat5), an enzyme in the Asn (N)-linked protein glycosylation pathway, as a potent
negative regulator of T cell activation and autoimmunity in mice
(Demetriou et al (2001) Nature 409 733). Mgat5 glycans limit T cell receptor (TCR) clustering at the immune synapse, decrease TCR signaling and reduce T cell proliferation by maintaining the TCR complex within a cell surface multi-valent galectin-glycoprotein lattice that restricts receptor movement in the plane of the membrane. Dr. Demtriou's lab is currently further defining the structure and function of the T cell galectin-glycoprotein lattice and its role in regulating T cell homeostasis and autoimmunity. |
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| Office Address/Phone: |
University of California, Irvine, Sprague Hall, Rm 208, 839 Medical Sciences Court
949-824-9775 |
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| Lab Address/Phone: |
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| Email: mdemetri@uci.edu |
| Web Site: http://www.ucihs.uci.edu/microbio/index.html?top.html&menu.html&facultyResearch/faculty/demetriou.html |
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