Sudhir Gupta, M.D., Ph.D.


Dr. Gupta is a Professor of Medicine, Pathology & Laboratory Medicine, and Microbiology & Molecular Genetics. He is also Chief, Division of Basic and Clinical Immunology, Director of the Program in Primary Immunodeficiency and Aging and Director of the Jeffrey Modell Foundation Diagnostic Center for Primary Immunodeficiencies. He is also a Member of the Cancer Research Institute and the Institute for Immunology.

Research Interests

Genetic basis of primary immunodeficiency diseases, functional and molecular characteristics of CD8 Treg in health and diseases. B cell biology in primary immunodeficiency diseases. T follicular helper and T follicular regulatory cells.


  • M.D.-King George’s Medical College, Lucknow
  • Ph.D -king George’s Medical College, Lucknow
  • Diplomat, American Boards in Diagnostic Laboratory Immunology
  • Boards in Clinical Immunology, Royal College of Physicians and Surgeons of Canada.

Academic Distinction:

  • Doctor of Science (Honoris causa), King George’s Medical University, Lucknow
  • Election to Henry Kunkel Society
  • Elected as F.R.C.P. (Lond)
  • Establishment of Sudhir Gupta Oration Lecture in Primary Immunodeficiency Diseases (ISPID)


  • Lois AG, Yel L, Cao J, Agarwal S, GUPTA S, Common variable immunodeficiency associated with microdeletion of chromosome 1q41.1-41.3 and a deficiency of IP3 kinaseβ. Clin.Trans. Immunol. 2015; 5
  • Gupta S, Agrawal S, Gollapudi S, and Kubagawa H.  FcuR in human B cell subsets in primary selective IgM deficiency, and regulation of FcuR and production of natural IgM antibodies by IGIV. Human Immunology  77: 1194-2001, 2016
  • Gupta S, and Gupta A. Selective IgM degiciency-An underestimated primary immunodeficiency. Front. Immunology 8:1056. Doi: 10.3389/immu.2017.01056, 2017
  • Agrawal A, Agrawal S and Gupta S Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly. Front. Immunol. 8:896. doi: 10.3389/fimmu.2017.00896
  • Gupta S, Su H, Gollapudi S. Molecularchanges associated with of TNF-α-induced apoptosis in naïve(TN) and central memory (TCM) CD8+ T cells in aging.  Ageing Immunity 15: 2. 12979-017-0109-0, 2018
  • Agarwal S, Khokar A, Gupta S. CMV colitis in primary hypogammaglobulinemia with normal CD4+T cells but deficiency of CMV-speficific CD8 T cells. Front. Immunol. doi: 10.3389/fimmu.2019.00399
  • Kasahara TM, Bento CAM, GUPTA S. Phenotypic analysis of T Follicular Helper and T follicular regulatory cells in primary selective IgM deficiency. Mol. Immunol 2020 Aug 7: S0198-8859(20)30371-2. doi: 10.1016/j.humimm.2020.07.008.
  • GUPTA S, Su H, Agrawal S. CD8 Treg Cells Inhibit B cell Proliferation and Immunoglobulin Production. Int. Arch. Allergy Immunol. 2020 Aug 14:1-9. doi: 10.1159/000509607. Online ahead of print. PMID: 32799212
  • Kasahara TM, Bento CAM, GUPTA S. Phenotypic and functional analysis of T follicular helper cells in common variable immunodeficiency. Int. Arch. Allergy Immunol pp 1-13; doi:10.1159/000507995



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