Amanda McQuade


Amanda is a graduate student in the Burton-Jones lab.

Research Interests

My works focuses on understanding how the innate immune cells of the brain, microglia, contribute to the onset of Alzheimer's disease. Alzheimer's disease is the most common form of progressive dementia and still has no cure. In order to develop targeted therapies, we must first understand what is causing Alzheimer's disease. Recent evidence shows that microglia may be a key player in the progression of Alzheimer's disease, so in order to study this, our lab has developed a protocol to differentiate human microglia from induced-pluripotent stem cells. Using these cells, I am studying specific micrglia-enriched genes that are associated with Alzheimer's disease in order to determine what role microglia play in disease pathogenesis. 


3200 Gross Hall
(949) 824-0369